Serum Lp-PLA2: as a novel viewpoint in periodontal treatment of hyperlipidaemics

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Serum Lp-PLA2: as a novel viewpoint in periodontal treatment of hyperlipidaemics.

BACKGROUND/AIM To evaluate the effects of periodontal treatment on serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and C-reactive protein (CRP) levels in hyperlipidaemic patients with periodontitis. MATERIALS AND METHODS The study included 52 hyperlipidaemics and 28 systemically healthy controls (C) with periodontitis. Of the 52 hyperlipidaemics, 29 received a suggested diet (HD), and...

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Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles

Aims Darapladib, a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), has not reduced risk of cardiovascular disease outcomes in recent randomized trials. We aimed to test whether Lp-PLA2 enzyme activity is causally relevant to coronary heart disease. Methods In 72,657 patients with coronary heart disease and 110,218 controls in 23 epidemiological studies, we genotyped five ...

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Lp-PLA2 levels in HIV-infected patients

INTRODUCTION HIV-infected patients show an increased risk of cardiovascular disease (CVD). In the general population, lipoprotein-associated phospholipase A2 (Lp-PLA2) appears to be an independent predictor of CVD. We aimed to study associations between Lp-PLA2 plasma levels and other risk factors for CVD in HIV patients. MATERIALS AND METHODS A cross-sectional, comparative study of two serie...

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Lipoprotein-associated phospholipase A2 (Lp-PLA2)

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Lipoprotein-associated phospholipase A2 (Lp-PLA2)

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ژورنال

عنوان ژورنال: TURKISH JOURNAL OF MEDICAL SCIENCES

سال: 2015

ISSN: 1300-0144,1303-6165

DOI: 10.3906/sag-1406-75